Rosario martinez vega singapore professional profile. This observational study reports the survival and virologic suppression of patients on secondline art under programmatic condition and type of mutations acquired by those failing therapy. Tenofovirbased antiretroviral therapy in hepatitis b virus hiv coinfection. The treat asia paediatric hiv observational database impaact. Singapore database coordinator of treat asia hiv observational database. Mcgowan cc, cahn p, gotuzzo e, padgett d, pape jw, wolff m, schechter m, masys dr. Research article open access trends in cd4 counts in. Pediatric late outcomes protocol pactgimpaact 219219c and a prospective surveillance study of longterm outcomes in hiv infected infants, children and adolescents impaact p1074 treat asia pediatric hiv observational database taphodiedea.
Incidence of syphilis seroconversion among hivinfected. Citeseerx document details isaac councill, lee giles, pradeep teregowda. Workshops mission the international workshop on hiv and hepatitis observational databases iwhod brings senior and junior hiv and hepatitis observational database researchers together to advance the methodology and analysis of observational data. We used survival methods to assess the association between older age and allcause mortality, as well as timeto treatment modification. National institutes of health global hiv research program iedea international epidemiologic databases to.
Observational data are collected on hiv infected patients. The occurrence of simpsons paradox if sitelevel effect was. This study aims to assess rates of hbv and hcv coinfection, and their impact on response to antiretroviral therapy and mortality, using data from the treat asia hiv observational database tahod, a multi. Treat asia pediatric hiv observational database center for. The significance of hiv blips in resourcelimited settings. Elaborated research proposals to answer clinical questions on hiv diagnosis and prognosis.
As australias most comprehensive hiv and aids collection, this database is designed to provide invaluable information support for doctors, health care workers and allied professionals, students, researchers and people living with hivaids. Data from tahod, the therapeutics research, education, and aids training in asia treat asia hiv observational database, were used in this study. The treat asia program of amfar the foundation for aids research, established the treat asia hiv observational database tahod in 2003, aimed at. Cd8 ratio comparison between cohorts of hivpositive. Patients enrolled in the treat asia hiv observational database cohort and with a negative nontreponemal test since enrolment were analyzed. Introduction magnitude and frequency of hiv viral load blips in resourcelimited settings, has not previously been assessed. Abstract abstract background this retrospective survey describes types of cancers diagnosed in hiv infected subjects in asia, and assesses risk factors for cancer in hiv infected subjects using contemporaneous hiv infected controls without cancer. Treat asia is a cooperative network of clinicians throughout asia and the pacific that aims to expand the capacity for broader introduction of hiv aids in the region. The information gathered through the treat asia hiv aids observational database tahod is intended to inform the development of more effective research and treatment programs, and ultimately could help to define treatment standards for asia and the pacificstandards that may differ from those in europe and the u. The treat asia hiv observational database tahod is a multisite adult hiv observational cohort with data from countries across asia. Hepatitis b and c coinfection in hiv patients from the. Yrg care and sri ramachandra medical university sign a. The hivaids database hiva consists of the library catalogues from the following organisations.
Pdf trends in firstline antiretroviral therapy in asia. Late presentation into care of hiv disease and its. Nov 27, 2014 among its accomplishments, the company has pioneered research that ultimately led to the use of antiretroviral drugs to block mothertoinfant hiv transmission. A similar project, the treat asia paediatrics hiv observational database taphod is designed to collect and. Impact of drug classes and treatment availability on the rate. Trends in mortality among arttreated hiv infected adults in the asia pacific region between 1999 and 2017.
The treat asia collaboration unsw the kirby institute for. This study examines the proportion of patients in the treat asia hiv observational database tahod receiving pcp prophylaxis, and its effect on pcp and mortality. Risk and prognostic significance of tuberculosis in patients from the treat asia hiv observational database. The treat asia hiv observational database baseline and. Taphod was established in 2007 in response to a need for better information about treatment and care of hiv infected children living in this region.
Elevated cd8 tcell counts and virological failure in hivin. Ahod is an observational cohort study of more than 4,000 hiv positive patients in australia under routine clinical care. With earlier antiretroviral therapy art initiation, time spent in hiv care is expected to increase. Pneumocystis jiroveci pneumonia pcp prophylaxis is recommended for patients with cd4 counts of less than 200 cellsmm 3. The treat asia hiv observation database, a contributor to the asia pacific iedea region, is jointly supported by the foundation for aids research amfar, the dutch ministry of foreign affairs, and stichting aids fonds. Caribbean, central and south america network for hiv research ccasanet collaboration within the international. The treat asia hiv observational database low intensity transfer tahodlite cohort is a substudy of the treat asia hiv observation database tahod and currently consists of eight sites from. We aimed to characterize the incidence and temporal trends of syphilis among hiv infected msm compared with hiv infected nonmsm in asian countries. Backgroundrelatively little is known regarding hiv disease natural history and response to antiretroviral treatments among asian people infected with hiv. National institutes of healths national institute of allergy and infectious diseases, eunice kennedy shriver national institute of child health and human development, national. Methods treat asia hiv observational database low intensity transfer tahodlite. Nov 18, 2014 the asia pacific hiv observational database aphod is part of the international epidemiological databases evaluating aids iedea collaboration and consists of two adult cohorts, the australian hiv observational database ahod and the treat asia hiv observational database tahod, as well as one paediatric cohort, the treat asia paediatric. Predictors of clinical progression in hiv1infected adults.
Results from the treat asia hiv observational database david c boettiger1, stephen kerr1,2, rossana ditangco3, romanee chaiwarith4, patrick ck. Results from the treat asia hiv observational database article pdf available in plos one 99. Australia hiv observational database ahod and treat asia hiv observation database tahod. Clinical science the treat asia hiv observational database baseline and retrospective data, year. The australian hiv observational database temporary residents. Tahod the treat asia hiv observational database home. We examined predictors of disease progression in patients in. A decade of combination antiretroviral treatment in asia.
The treat asia hiv observational database tahod was established in 2003 comprising 23 urban referral sites in countries across the region. Mortality of hiv1infected patients in the first year of. Typically, sdv involves the partial or complete comparison of research study data against original source documents, such as study case report forms, patient clinical charts, laboratory reports, or electronic health records. The treat asia pediatric hiv observational database is an initiative of treat asia, a program of amfar, the foundation for aids research, with support from the u. The australian hiv observational database temporary residents access study atras commenced in november 2011. The australian hiv observational database ahod unsw the. Trends in cd4 cell count response to firstline antiretroviral treatment in hivpositive patients from asia, 200320. The treat asia hiv observational database tahod and the australian hiv observational database ahod are initiatives of treat asia, a programme of amfar, the foundation for aids research, with support from the u. The treat asia hiv observational database, treat asia studies to evaluate resistance, and the australian hiv observational database are initiatives of treat asia, a program of amfar, the foundation for aids research, with support from the dutch ministry of foreign. Data were combined via standardized formats using microsoft excel software. The therapeutics research, education, and aids training in asia treat asia hiv observational database tahod is a recently established collaborative observational cohort study that aims to assess hiv disease natural history in treated and untreated patients in the asia pacific region. The treat asia pediatric hiv observational database.
Aidsdefining illness diagnosed within 90 days after. By jialun zhou, julian elliott, patrick ck li, poh lian lim. In 2014, ahod was expanded to include clinical sites in new zealand. Impact of gender on longterm treatment outcomes of highly active antiretroviral therapy haart in the treat asia hiv observational database. The information gathered through the treat asia hiv aids observational database tahod is intended to inform the development of more effective research and treatment programs, and ultimately could help to define treatment standards for asia and the pacificstandards that may differ from those in europe and the united states. Universal definition of loss to followup in hiv treatment. Mar 11, 2006 patients starting haart in resourcepoor settings have increased mortality rates in the first months on therapy, compared with those in developed countries. Cancers in the treat asia hiv observational database tahod. The therapeutics research, education, and aids training in asia treat asia hiv observational.
Incidence of syphilis seroconversion, defined as a positive nontreponemal test after previously. Trends in cd4 cell count response to firstline antiretroviral treatment in hiv positive patients from asia, 200320. We examined trends in treatment outcomes in patients who initiated cart between 2003 and 20. Dr kathleen falster school of public health and community. Competing risk and poisson regression were used to analyse the association between fpg and mortality, and assess risk.
Longterm virological outcomes of firstline antiretroviral. Iedea asia pacific 2019, trends in mortality among arttreated hiv infected adults in the asia pacific region between 1999 and 2017. At present, there are relatively few data available regarding hiv disease in the asia and pacific region. National institutes of healths national institute of allergy and infectious diseases, eunice kennedy shriver national institute of child health and human development, and national. Treat asia therapeutics research, education, and aids training in asia asia is a cooperative network of clinicians throughout asia and the pacific that aims to expand the capacity for broader introduction of hiv aids treatments in the region. All iedea publications 2015now iedea international. The treatment outcomes of antiretroviral substitutions in routine clinical settings in asia. The treat asia hiv observational database researchgate.
Asian countries have seen the expansion of combination antiretroviral therapy cart over the past decade. The collaboration with treat asia, a program of the foundation for aids research, evaluates the. Early mortality after late initiation of antiretroviral. We assessed the effects of hepatitis b hbv or hepatitis c hcv coinfection on outcomes of antiretroviral therapy art in hiv infected patients enrolled in the treat asia hiv observational database tahod, a multicenter cohort of hiv infected patients in the asia. The treat asia hiv observational database europe pmc. Cancers in the treat asia hiv observational database. Hiv and aids surveillance data are used to allocate resources for patient care, target hiv prevention activities, and evaluate the impact of public health recommendations. At present, there are relatively few data available regarding hiv disease in the asia. In this study, we describe the rate of treatment change among patients taking d4t3tcnvp in tahod and. The treat asia pediatric hiv observational database is supported in part by grants from the austrian aids life association and the us national institutes of health, through the eunice kennedy shriver national institute of child health and human development and the national institute of allergy and infectious diseases through the international. Describe time trends in, and risk factors for, overall survival in hiv positive patients receiving first line art from the asia pacific region. Treat asia hiv observational database yonsei university.
Finally, unpublished cohort data from the panafrican studies to evaluate resistance monitoring paserm program and treat asia tahod treat asia hiv observational database and taser treat asia studies to evaluate resistance programs were added as additional sources of data. Zhou j1, kumarasamy n, ditangco r, kamarulzaman a, lee ck, li pc, paton. Tahod, and the similar australian hiv observational database ahod have shown collection and collation of a limited number of core data variables from different clinical sites is a feasible method for creating a useful hiv database. Law and treat asia and hiv observational database, title brief report.
For each diagnosis, the following data were recorded. Trends in mortality among arttreated hivinfected adults. Patients from the therapeutics research, education, and aids training in asia treat asia hiv observational database low intensity transfer tahod. Incidence of postsuppression virologic rebound in perinatally. National institutes of healths national institute of allergy and infectious diseases, the eunice kennedy shriver national. Sep 17, 2007 data from tahod, the therapeutics research, education, and aids training in asia treat asia hiv observational database, were used in this study. Risk and prognostic significance of tuberculosis in. Briefly, tahod enrols patients with hiv from 21 adult treatment centres in 12 countries and ter ritories in asia, with the aim of assessing hiv disease natural history in treated and untreated patients in the region. Hiv, antiretroviral treatment, observational database, asia and the. Request pdf the treat asia hiv observational database. The treat asia hiv observational database is an initiative of treat asia, a program of amfar, the foundation for aids research.
Hiv viral suppression in treat asia hiv observational database. Antiretroviral treatment interruption and loss to followup in two hiv cohorts in australia and asia. Hepatitis b and c virus coinfection in the treat asia hiv. Patients enrolled in tahod receive clinical care according to treatment guidelines and protocols relevant to their treatment center.
The treat asia hiv observational database is an initiative of treat asia, a program of amfar, the foundation for aids research, with support from the u. Shortterm clinical disease progression in hivinfected. Tenofovirbased antiretroviral therapy in hbvhiv co. Source document verification sdv is a strategy for research data quality assessment.
Longterm loss to followup in the treat asia hiv observational database tahod. Over time, there have been changes to treatment and patient management and monitoring. Outcome of patients on second line antiretroviral therapy. Diabetes, mortality and glucose monitoring rates in the. Pdf the treat asia hiv observational database rossana. National institutes of healths national institute of allergy and infectious diseases, eunice kennedy shriver national institute of child health and human development, and. Citeseerx the treat asia hiv observational database. Virat sirisanthana, on behalf of the treat asia pediatric hiv observational database 9 december 20 aids patient care and stds, vol. The treat asia hiv observational database tahod is the first collaborative study by the treat asia network.
Relatively little is known regarding hiv disease natural history and response to antiretroviral treatments among asian people infected with hiv the therapeutics research, education, and aids training in asia treat asia hiv observational database tahod is a recently established collaborative observational cohort study that aims to assess hiv disease natural history in. R bijker, a jiamsakul, e uy, n kumarasamy, r ditango, r chaiwarith, w w wong, a avihingsanon, l p sun, e yunihastuti, s pujari, c d do, t p merati, p kantipong, k v nguyen, a kamarulzaman, f zhang, m p lee, j y choi, j tanuma, o t ng, blh sim, j ross, s kiertiburanakul, treat asia hiv observational database tahod of iedea asia pacific 2019. The national aids control organization of india has been providing free second line antiretroviral therapy art since 2008. Longterm loss to followup in the treat asia hiv observational. Hiv viral suppression in treat asia hiv observational database enrolled. In these analyses asian and caucasian status were defined by cohort.
Patients enrolled in the treat asia hiv observational database cohort and with a negative non. The aims of this study were to examine the relationship between trends in cd4 count and vl after initiation of combination antiretroviral treatment in hiv infected asian patients, using data from the treat asia hiv observational database. Plhiv enrolled in the therapeutics, research, education and aids training in asia treat asia hiv observational database tahod who initiated art with a cd4 count treat asia hiv observational database is part of the asia pacific hiv observational database and is an initiative of treat asia, a programme of amfar, the foundation for aids research, with support from the national institutes of health. Aug 01, 2016 despite the scaleup, cart coverage in asia reached only 33% of those living with hiv compared to 37% in the african region in 20. Patients starting three or more antiretroviral combinations and having subsequent followup were included. National institute of allergy and infectious diseases and the national cancer institute, as part of the. Patients from the australian hiv observational database ahod and the treat asia hiv observational database tahod were included in the analysis. The treat asia hiv observational database tahod is the first collaborative study by the treat asia. The impact of data quality and source data verification on. Healthrelated quality of life of perinatally hivinfected. The treat asia hiv observational database tahod is a collaborative study by the treat asia network, a cooperative network of clinicians throughout asia and the pacific, funded by the american foundation of aids research amfar 4.
Original article tenofovirbased antiretroviral therapy in. To assess the risk and the prognostic significance of tuberculosis tb diagnosis in patients from the treat asia hiv observational database, a multicentre prospective cohort of hiv infected patients receiving hiv care in the asia pacific region. It was established in 1999 to monitor treatment uptake and outcomes. The majority of hiv infected patients in developing countries commences combination antiretroviral therapy cart with advanced disease. Dr kathleen falster is a senior lecturer at the school of public health and community medicine at the university of new south wales unsw, sydney. Using data from treat asia hiv observational database tahod, this paper aims to assess the rate of, and factors associated with the diagnosis of new aidsdefining illness adi within 90 days after antiretroviral treatment. Atras provides antiretroviral treatments art via a compassionate access scheme for up to 4 years to 180 hiv positive patients who are temporary residents in australia and ineligible for medicare.
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